Biology Department Faculty
Peter Clote
Professor
Peter Clote
Ph.D.
Contact
Higgins Hall 577
Telephone: 617-552-1332
Email: peter.clote@bc.edu
ORCID
Education
- Sc.B., Massachusetts Institute of Technology
- Ph.D., Duke University
- Doctorat d'Etat, University of Paris VII
Research Interests
Computational biology/bioinformatics, synthetic biology, structural and systems biology, RNA molecular design, kinetics, RNA tertiary structure motifs, macromolecular structure, molecular evolution, machine learning in bioinformatics (neural nets, support vector machines).
Department
Research
RNA plays a wide range of previously unsuspected roles in many biological processes, including retranslation of the genetic code (selenocysteine insertion, ribosomal frameshift transcriptional and translational gene regulation, temperature sensitive conformational switches, chemical modification of specific nucleotides in the ribosome, regulation of alternative splicing, etc.).
Our lab is interested in such questions, especially in the development of new thermodynamics-based algorithms to better understand the folding and folding kinetics of such RNA. We are interested in the computational design of synthetic ribozymes (ribonucleic acid enzymes), synthetic riboswitches (RNAs that regulate genes by allostery), synthetic thermozymes (regulatory RNAs that are triggered by temperature change) and other RNA classes -- work that contributes to synthetic biology, the "wet" analogue of nanotechnology, a field that could be dominant in the 21st century.
Selected Publications
More publications can be viewed on
- P. Clote, A. Bayegan. . J Math Biol, in press (2017), arXiv article ID 1707.03922.
- Bayegan AH and Clote P. "", Workshop on Algorithms in Bioinformatics (WABI 2017), August 21-23, 2017, Boston, MA. WABI2017 is part of the eighth ACM-BCB 2017 (ACM Conference on Bioinformatics, Computational Biology and Health Informatics).
- Bayegan AH, Garcia-Martin JA, and Clote P. . BMC Bioinformatics. 2016 Dec 13;17(1):530.
- Garcia-Martin JA, Dotu I, Fernandez-Chamorro J, Lozano G, Ramajo J, Martinez-Salas E, Clote P. . Bioinformatics. 2016 Jun 15;32(12):i360-i368. doi: 10.1093/bioinformatics/btw265.
- Clote P, Bayegan A. . PLoS One. 2015 Oct 21;10(10):e0139476. doi: 10.1371/journal.pone.0139476.
- Garcia-Martin JA, Dotu I, Clote P. 1. . Nucleic Acids Research Web Server issue, 2015, doi: 10.1093/nar/gkv460
- Senter E, Clote P. . J Comp Biol, Vol. 22, No. 2, February 2015: 124-144.
- Dotu I, Garcia-Martin JA, Slinger BL, Mechery V, Meyer MM, Clote P. . Nucleic Acids Res. 2015 Feb 1;42(18):11752-62. doi: 10.1093/nar/gku740.听
- Clote P. . J Comput Chem. 2015 Jan 15;36(2):103-17. doi: 10.1002/jcc.23776.听
- Dotu I, Lozano G, Clote P, Martinez-Salas E. . RNA Biol. 2013 Dec 1;10(12):1842-52. doi: 10.4161/rna.26994.听
- Senter E, Sheikh S, Dotu I, Ponty Y, Clote P. 听. PLoS One. 2012;7(12):e50506. doi: 10.1371/journal.pone.0050506.
- K. Zarringhalam, M.M. Meyer, I. Dotu, J.H. Chuang, P. Clote. . PLoS One. 2012;7(10):e45160. doi: 10.1371/journal.pone.0045160.听
- P. Clote, Y. Ponty, J.-M. Steyaert. . J Math Biol. 2012 Sep;65(3):581-99.听
- P. Bochet, F. R眉heimer, T. Guina, P. Brooks, D. Goodlett, P. Clote, B. Schwikowski.听听Proteomics, 2011 Jan;11(1):22-32.
- Feng Lou, Peter Clote.听.听ISMB2010,听Bioinformatics听2010 Jun 15;26(12):i278-86.
- I. Dot煤, W.A. Lorenz, P. Van Hentenryck, P. Clote. . Nucleic Acids Res. 2010 Mar 1;38(5):1711-22.听
- Eva Freyhult; Vincent Moulton; Peter Clote. . Bioinformatics. 2007 Aug 15;23(16):2054-62.
- F. Ferre, P. Clote.听, Nucleic Acids Res. 34(Web Server issue):W182-5 (2006).听
- P. Clote, F. Ferre, E. Kranakis, D. Krizanc.听. RNA, 11(5):578-591 (2005).听
- F. Ferre and P. Clote.听, Bioinformatics 21(10)